Gene-Editing Technology Accelerates Cardiovascular Research

gene therapy in cardiovascular research

Gene Therapy in Cardiovascular Research

* Corresponding author: Arpad Tosaki, Department of Pharmacology, Faculty of Pharmacy, Health and Science Center, University of Debrecen, Debrecen, Hungary, Tel/Fax: +36-52-255586, E-mail: [email protected] © 2012 School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Published by DocS. This is an Open Access article distributed under the terms of the Creative Commons ...

Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.

Until very recently, the prospect of introducing mutations or exogenous DNA sequences at precise locations in the genomes of plants and animals was difficult, if not impossible. This rapidly changed with the demonstration that the type II CRISPR-Cas complex, a bacterial anti-viral surveillance system, could be engineered into a simple and robust platform for introducing double-stranded DNA brea...

Gene Editing: Powerful New Tools for Nephrology Research and Therapy.

Biologic research is experiencing a transformation brought about by the ability of programmable nucleases to manipulate the genome. In the recently developed CRISPR/Cas system, short RNA sequences guide the endonuclease Cas9 to any location in the genome, causing a DNA double-strand break (DSB). Repair of DSBs allows the introduction of targeted genetic manipulations with high precision. Cas9-m...

Opportunities for CRISPR/Cas9 Gene Editing in Retinal Regeneration Research

While retinal degeneration and disease results in permanent damage and vision loss in humans, the severely damaged zebrafish retina has a high capacity to regenerate lost neurons and restore visual behaviors. Advancements in understanding the molecular and cellular basis of this regeneration response give hope that strategies and therapeutics may be developed to restore sight to blind and visua...